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Testosterone therapy associated with lower risk of aggressive prostate cancer

Male Hormones

Testosterone therapy associated with lower risk of aggressive prostate cancer

The results of a recent analysis of 231,408 medical records has failed to find an association between testosterone replacement therapy and an increased risk of prostate cancer, and furthermore determined that the therapy appears to be associated with a lower risk of aggressive disease. The findings, presented on May 9, 2016 at the American Urological Association's annual meeting, were uncovered by a study led by researchers at New York University (NYU) Langone Medical Center and the Laura and Isaac Perlmutter Cancer Center. Stacy Loeb, MD, MSc, and colleagues utilized records from the National Prostate Cancer Register and the Prescribed Drug...

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Male hormone stimulates telomerase production

Male Hormones

Male hormone stimulates telomerase production

The May 19, 2016 issue of the New England Journal of Medicine reported the outcome of a study conducted by the National Institutes of Health and researchers in Brazil that found an increase in telomerase in association with androgenic hormone treatment. "One of the processes associated with aging is progressive shortening of telomeres, DNA-protecting structures at the ends of chromosomes, like the plastic tips on shoelaces," explained coauthor Rodrigo Calado, who is a professor at the University of São Paulo's Ribeirão Preto Medical School. "Each time a cell divides, its telomeres get shorter. Eventually, the cell can't replicate anymore and dies...

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Meta-analysis concludes beneficial effect for testosterone replacement on body composition, glucose

Male Hormones

Meta-analysis concludes beneficial effect for testosterone replacement on body composition, glucose

The March 2016 issue of the European Journal of Endocrinology published a meta-analysis of randomized trials and observational studies that affirmed an association between testosterone supplementation and improvement in body composition, glucose levels and insulin resistance. For their analysis, Italian researchers identified 59 randomized controlled trials and observational studies that provided information on varying aspects of body composition in 3,029 men receiving testosterone and 2,049 control subjects. Not surprisingly, use of any testosterone preparation was associated with higher testosterone levels. Supplementing with testosterone was associated with a significant reduction in fat mass and an increase in lean body mass. Fasting...

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NHANES analysis adds evidence to vitamin deficiency-ED link

NHANES analysis adds evidence to vitamin deficiency-ED link

The results of an analysis of participants in the National Health and Nutrition Examination Survey (NHANES) 2001-2004 provides more evidence for an association between vitamin D deficiency and an increased risk in vascular erectile dysfunction. The findings were published in the September 2016 issue of the journal Atherosclerosis. The study included 3,390 men participants in NHANES 2001-2004 who were free of atherosclerotic cardiovascular disease. Results of blood tests for serum 25-hydroxyvitamin D were categorized as deficient, intermediate or optimal. Seven hundred seventy-five men reported having ED. In all statistical models, the incidence of ED rose in association with decreasing levels...

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Soy isoflavones could help lower insulin in women with PCOS

Soy isoflavones could help lower insulin in women with PCOS

An article appearing on August 4, 2016 in the Journal of Clinical Endocrinology & Metabolism reveals a potential benefit for soy isoflavones for women with polycystic ovary syndrome (PCOS)--a disorder characterized by mildly elevated male hormones and insulin which is associated with weight gain, infertility, and a greater risk of diabetes and coronary heart disease. The condition is estimated to affect 5 to 6 million U.S. women. In a randomized trial, 70 women aged 18 to 40 years with PCOS were assigned to consume 50 milligrams per day of a soy isoflavone supplement or a placebo for 12 weeks. Blood...

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