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Study finds fewer hospital readmissions among men treated with testosterone

Male Hormones

Study finds fewer hospital readmissions among men treated with testosterone

A study reported in the May 2016 issue of Mayo Clinic Proceedings uncovered a lower rate of hospital readmission among men who received testosterone replacement compared to untreated men. Previous research has found a decrease in muscle mass and strength in association with hospitalization among older men that is linked to an increased risk of readmission. Testosterone is an androgenic hormone that helps maintain muscle mass, among other benefits. Jacques Baillargeon and colleagues at the University of Texas Medical Branch in Galveston analyzed SEER-Medicare linked data for 6,372 men aged 66 years and older with low testosterone levels who were hospitalized from 2007...

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Testosterone therapy associated with improved sexual function in diabetic men with severely low hormone levels

Male Hormones

Testosterone therapy associated with improved sexual function in diabetic men with severely low hormone levels

An article appearing on May 27, 2016 in BJU International reveals better sexual function in men with type 2 diabetes with severely depressed hormone levels who were treated with testosterone undecanoate. Type 2 diabetes, as well as deficient testosterone levels, have been linked to a decline in sexual function in aging men. The study included 189 men, among whom 107 had mild hypogonadism and 87 had severe hypogonadism as demonstrated by low total and free serum testosterone levels. Participants received 1,000 milligrams testosterone undecanoate or a placebo at the beginning of the study and at 6 and 18 weeks. Questionnaires that assessed erectile...

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Testosterone therapy associated with lower risk of aggressive prostate cancer

Male Hormones

Testosterone therapy associated with lower risk of aggressive prostate cancer

The results of a recent analysis of 231,408 medical records has failed to find an association between testosterone replacement therapy and an increased risk of prostate cancer, and furthermore determined that the therapy appears to be associated with a lower risk of aggressive disease. The findings, presented on May 9, 2016 at the American Urological Association's annual meeting, were uncovered by a study led by researchers at New York University (NYU) Langone Medical Center and the Laura and Isaac Perlmutter Cancer Center. Stacy Loeb, MD, MSc, and colleagues utilized records from the National Prostate Cancer Register and the Prescribed Drug...

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Male hormone stimulates telomerase production

Male Hormones

Male hormone stimulates telomerase production

The May 19, 2016 issue of the New England Journal of Medicine reported the outcome of a study conducted by the National Institutes of Health and researchers in Brazil that found an increase in telomerase in association with androgenic hormone treatment. "One of the processes associated with aging is progressive shortening of telomeres, DNA-protecting structures at the ends of chromosomes, like the plastic tips on shoelaces," explained coauthor Rodrigo Calado, who is a professor at the University of São Paulo's Ribeirão Preto Medical School. "Each time a cell divides, its telomeres get shorter. Eventually, the cell can't replicate anymore and dies...

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Meta-analysis concludes beneficial effect for testosterone replacement on body composition, glucose

Male Hormones

Meta-analysis concludes beneficial effect for testosterone replacement on body composition, glucose

The March 2016 issue of the European Journal of Endocrinology published a meta-analysis of randomized trials and observational studies that affirmed an association between testosterone supplementation and improvement in body composition, glucose levels and insulin resistance. For their analysis, Italian researchers identified 59 randomized controlled trials and observational studies that provided information on varying aspects of body composition in 3,029 men receiving testosterone and 2,049 control subjects. Not surprisingly, use of any testosterone preparation was associated with higher testosterone levels. Supplementing with testosterone was associated with a significant reduction in fat mass and an increase in lean body mass. Fasting...

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