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Progesterone may help protect the lungs during flu

Female Hormones Influenza Progesterone

Progesterone may help protect the lungs during flu

A report appearing on September 15, 2016 in the journal PLOS Pathogens describes a role for the hormone progesterone in reducing inflammation and improving lung function following infection with influenza.

"Epidemiological and experimental evidence suggest that young adult females suffer a worse outcome than males following influenza A virus infection, which in mice is associated with infection-induced suppression of reproductive hormones and excessive inflammatory immune responses in females," write Sabra L. Klein of Johns Hopkins University and colleagues. "In addition to influenza, young adult females suffer a worse outcome than males from several autoimmune diseases, including multiple sclerosis. Paradoxically, a...

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Metformin could delay heart disease in type 1 diabetics

Metformin could delay heart disease in type 1 diabetics

Research reported on August 26, 2016 in Cardiovascular Diabetology suggests a use for metformin, commonly used to treat type 2 diabetes, to delay the development of heart disease in type 1 diabetics.

Twenty-three type 1 diabetics with no evidence of heart disease were given metformin in addition to standard therapy for eight weeks while nine type 1 diabetics received standard insulin therapy. Twenty-three healthy nondiabetics served as a control group. Circulating endothelial progenitor cells, proangiogenic cells, endothelial cells and other factors were assessed before and after the treatment period.

"For the first time, this study has shown metformin has additional...

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Supplementation with vitamin D associated with improved testosterone, erectile function among middle-aged men

Male Hormones Vitamin D

Supplementation with vitamin D associated with improved testosterone, erectile function among middle-aged men

A study reported on January 11, 2017 in The Aging Male found improvements in testosterone levels, erectile function and indicators of metabolic syndrome among men who received vitamin D over a one year period. “Given that patients with low total testosterone often have low vitamin D levels, collectively, research suggests a relationship between low vitamin D and low total testosterone, and increased risk of type 2 diabetes mellitus,” note Ondor Canguven of Hamad General Hospital in Doha, Qatar and colleagues.

The study included 102 men between the ages of 35 to 65 with vitamin D levels of less than 30...

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Higher DHEA levels associated with lower diabetes risk

diabetes Female Hormones Male Hormones

Higher DHEA levels associated with lower diabetes risk

Diabetologia reports an association between higher serum levels of the hormone dehydroepiandrosterone (DHEA) and a lower risk of type 2 diabetes.

The investigation involved participants in the Rotterdam Study, which enrolled 7,983 men and women aged 55 and older from 1990–1993 (Rotterdam Study I) and 3,011 participants in 2000 (Rotterdam study II). Follow–up visits were conducted every three to five years. Serum levels of DHEA, its derivatives DHEA–sulfate and androstenedione, and other factors were measured during Rotterdam Study I subjects' third visit and at enrollment in Rotterdam Study II.

The current study was limited to 5,189 subjects who were free...

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Testosterone treatment of older men ignites sexual interest, activity

Male Hormones

Testosterone treatment of older men ignites sexual interest, activity

An article published in the August 2016 issue of the Journal of Clinical Endocrinology & Metabolism reports increased sexual interest and activity among men over the age of 65 years receiving testosterone replacement therapy.

Testosterone is a hormone that declines with age in humans. An increasing number of men are opting to receive testosterone replacement when indicated by blood test results. The current investigation, which is part of the Testosterone Trials series, is the largest of its kind to date among men in this age group.

Four hundred-seventy men aged 65 and older with low libido and testosterone levels of less than...

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